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VERSION:2.0
PRODID:icalendar-ruby
CALSCALE:GREGORIAN
METHOD:PUBLISH
BEGIN:VEVENT
DTSTAMP:20260928T013805Z
UID:https://www.mpgc-mainz.de/events/30801/2368
DTSTART;VALUE=DATE:20220525
DTEND;VALUE=DATE:20220526
CLASS:PUBLIC
CREATED:20220408T082609Z
DESCRIPTION:The first broadly applicable and sustainable electrochemical sy
 nthesis of N\,N’ disubstituted indazolin-3-ones by direct intramolecular
  anodic dehydrogenative N-N coupling reaction is presented. This method fe
 atures mild reaction conditions\, an easy experimental setup\, sustainable
  and inexpensive electrode materials and a low supporting electrolyte conc
 entration\, providing access to various indazolin-3-one derivatives in goo
 d yields up to 78%. The reaction conditions were optimized applying the st
 atistics-based method Design of Experiments (DoE) and the excellent scalab
 ility of the reaction was demonstrated. Additionally\, cyclic voltammetry 
 experiments were conducted to get insights into the reaction mechanism. In
 dazolin-3-ones represent an important class of N-heterocycles due to their
  broad range of biological activity\, such as anti-inflammatory\, anticanc
 er and antichagasic properties. However\, conventional indazolin-3-one syn
 theses often involve harsh reaction conditions\, the use of toxic reagents
  in stoichiometric amounts or transition metal catalysts\, leading to larg
 e amounts of reagent waste\, high costs and safety hazards. In contrast\, 
 electro-organic chemistry has proven to provide a sustainable and broadly 
 applicable synthetic tool for the synthesis of various N-heterocycles. By 
 applying current as a traceless oxidant\, reagent waste can be diminished\
 , work safety increased and costs lowered.\nSpeaker: Jessica Bieniek
LAST-MODIFIED:20220427T092623Z
LOCATION:
SUMMARY:Jessica Bieniek: Electrochemical Synthesis of N\,N’-Disubstituted
  Indazolin-3-ones
URL;VALUE=URI:https://www.mpgc-mainz.de/events/30801/2368
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