Kerstin Schwickert: The human ion channel TRPML2 and its role in viral infections

  • Date: Jun 22, 2022
  • Speaker: Kerstin Schwickert
During the last years, ion channels have emerged as key host cell factors for a great number of viral infections and are even discussed as therapeutic targets against infectious diseases. Ion channels are involved in almost all aspects of life. One ion channel family playing a crucial role in the sensory physiology of various organisms is the Transient Receptor Potential (TRP) superfamily. These exclusively eukaryotic cation channels are polymodal; they are regulated by a variety of stimuli including lipids, ions, other proteins, temperature, pH, etc. One member of the TRP superfamily is TRPML2 which was recently revealed to enhance the infectivity of certain endocytosed viruses such as Zika, Dengue and West Nile virus. However, the molecular details of this enhancement remain elusive and need further investigation.
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