Johannes Strunk: Characterizing the Function of the Antiviral Intracellular Restriction Factor MYPOP and its Capability as Tumor Suppressor

  • Date: Jul 6, 2022
  • Speaker: Johannes Strunk
Transcription factors play a key role in regulating cellular processes through direct interaction with the cellular DNA, thereby influencing the rate of gene transcription. My project is about the fairly unknown transcription factor MYPOP that has previously been described as a negative regulator of transcription. Moreover, MYPOP has been described by our group as a novel antiviral restriction factor with additional functions in tumor suppression. With my work I was able to shed light on transcriptome changes induced by MYPOP that indicated a function in regulating cell cycle progression as well as inducing proinflammatory cytokine production. Together with collaboration partners, I was able to establish a MYPOP-mRNA-Lipoplex transfection system that allows for efficient overexpression of MYPOP in various human and murine cell lines. Here, I was able to show, that MYPOP consistently represses proliferation of various tumor cell lines while sparing normal human epithelial keratinocytes. These findings give hope to a possible application of MYPOP in future tumor therapies.
Go to Editor View